To reduce publication bias, we selected studies carefully and evaluated the trails with the STROBE guidelines.
Although endometrial cancer is the most common gynecologic malignancy, to date there have been only a few studies attempting to evaluate the expression of TRAIL receptors [ 14, 15].
As mice only harbors one apoptosis-inducing TRAIL receptor, equally homologous to both human apoptosis-inducing TRAIL receptors, DR4 and DR5, classical murine models are not suited to evaluate the toxicity of TRAIL-based treatments.
As mice only harbors one apoptosis-inducing TRAIL receptor, equally homologous to both human apoptosis-inducing TRAIL receptors, DR4 and DR5, classical murine models might not be suited to evaluate the toxicity of TRAIL-based treatments.
It should be noted that in the current study we did not evaluate the individual effectiveness of TRAIL against hCSCs, but TRAIL is currently in clinical trials in the US NCT005086255).
We also evaluated the charge trailing effect and tested a method for correcting its effects.
Although further research is required to dissect the underlying mechanisms and evaluate the potency of AFMC and TRAIL co-treatment in a nude mouse model, collectively, these results raise the possibility that combined treatment with TRAIL and AFMC could be a promising candidate therapeutic for human lung cancer.
Due to their clinical results, the authors of the study advocated the use of 'closely monitored clinical trails' to evaluate the efficacy and safety of porcine xenogenic therapies (Paradis et al. 1999, 1240).
In practice, sometimes different optimality criteria, or the same criterion with different regimes, need to be considered to assess the treatments in the same study, so that each mechanism is also evaluated through the trail study.
The aim of this pilot trail was to evaluate the effectiveness of an early psychological intervention with siblings of newly diagnosed pediatric cancer patients.
