Therefore, the development of a noninvasive and high-throughput analytical method is needed for evaluating the potency and efficacy of drugs in vitro during the early stages of drug discovery.
To design potent, safe and selective inhibitors of furin, we evaluated the potency and selectivity of the derivatized peptidic inhibitors modeled from the extended furin cleavage sequence of avian influenza A H5N1.
Here, we evaluate the potency, efficacy and durability of DNA/DNA, DNA-prime/Protein-boost, and Protein/Protein based vaccination against VL in a susceptible murine model.
Therefore, to evaluate the potency, efficacy and durability, a comparative study using either genetic or heterologous or protein-based vaccination with gp63 is required against VL.
Although further research is required to dissect the underlying mechanisms and evaluate the potency of AFMC and TRAIL co-treatment in a nude mouse model, collectively, these results raise the possibility that combined treatment with TRAIL and AFMC could be a promising candidate therapeutic for human lung cancer.
By investigating the effects of compounds on the biological pathway network, researchers can easily evaluate the potency of compounds and thus move basic biological discoveries into the clinic applications.
Further, presumably because of the restricted period of GC treatment, we could not evaluate the potency of our bioassay and binding assay to predict susceptibility for GC-mediated side effects.
Indeed, the use of red substrate would enable one to determine which cells have ALDH activity (ALDHbright) vs. the ones without (ALDHdim); it would then be possible to better characterize which fraction (ALDHbright or ALDHdim) correlates with a particular phenotype and to evaluate the potency of these subpopulations in vivo.
Then, we performed competitive ELISA to evaluate the potency of anti-ROBO1, DOTA-anti-ROBO1, and radioisotope (RI -labelled anti-RI -labelled
