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For example, for Amgen's candidate molecule ABP501, which is a biosimilar of adalimumab, an assay used Chinese hamster ovary (CHO) target cells (CHO M7, Amgen) to evaluate the induction of ADCC and CDC.
To evaluate the induction of FMDV-specific T cells as a result of vaccination, lymphoproliferation assays were carried out with PBMCs of vaccinated pigs.
These plates were then processed to evaluate the induction of apoptosis using the Apo-Alert activated caspase-3 assay.
The study protocol (Fig. 1) was designed to evaluate the induction of S-glutathionylation and recovery associated with both acute and chronic ROS exposure.
The genetic markers used to evaluate the induction of the HOG pathway in A. fumigatus included catA (catalase, Afu6g12180), dprA (dehydrin, Afu4g00860), and dprB (dehydrin, Afu6g12180).
To evaluate the induction of DON during infection, the green fluorescence protein (GFP) gene was fused to the promoter of the TRI5 gene, coding for the trichodiene synthase of the fungus.
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Further studies were designed with the aim of evaluating the induction of genotoxic and carcinogenic effects in Swiss albino mice exposed to smoke and/or light since birth.
We also evaluated the induction of senescence in these cells by analyzing the expression patterns of senescence and stemness marker genes.
We evaluated the induction of corticospinal silent period (SP) using transcranial magnetic stimulation (TMS) at stimulation intensities normalized to resting motor threshold (rMT) or silent period thresholds (SPTs).
We designed an experimental study aimed at evaluating the induction of possible noxious effects on testicular morphology and functions in A/J mice exposed whole-body to CS during the first 70 days of life, from birth to early adulthood.
We then evaluated the induction of SOCS3 mRNA and protein levels in cells transiently transfected with HBx.
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