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To evaluate the functional significance of genes expressed preferentially in japonica or indica, we queried the OGRO database with 594 genes to see if any of them were functionally characterized.
Deletion and targeted mutagenesis analysis was used to evaluate the functional significance of sequence blocks within the upstream fragment.
The idea was to evaluate the functional significance of a gene based on the concept of connectivity.
Mutations of the individual GC-box, as well as combined mutations were performed to evaluate the functional significance of these putative Sp binding sites.
To evaluate the functional significance of the six potential drug target sites, the regions were mapped to the PfGK structure (Figures 4C and 4D).
In an attempt to evaluate the functional significance of the different modules defined in gene expression experiments (signatures and co-expression modules) we have explored their internal connectivity.
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We next evaluated the functional significance of hexon and other structural proteins specific NAbs to suppress the immunogenicity of Ad3/H3 and Ad3/H7 vectors expressing EGFP in mice preimmunized with wild type Ad.
One of the problems raised by next-generation sequencing is evaluating the functional significance of newly identified rare variants.
However, our finding that RIDD promotes cell death highlights the importance of re-evaluating the functional significance of IRE1 activation.
Evaluating the functional significance of such mutations is challenging due to the difficulties in purifying such a large protein.
Ingenuity pathway analysis 3.1 software (IPA; Ingenuity Systems) was used for evaluating the functional significance of regulated gene profiles.
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