Sentence examples for evaluate the functional roles from inspiring English sources

Moreover, it is of equal importance to evaluate the functional roles of elevated ALDH1A3, ALDH3A2 and ALDH7A1 isozymes in ovarian cancer.

Several recent studies have begun to evaluate the functional roles of YAP and TAZ in mediating the response of cells to mechanical forces.

Although these models provide useful tools to study the functional roles of a certain generic-type ion channel current, they are not suitable to evaluate the functional roles of isoform-specific channels on cardiac pacemaking.

To further evaluate the functional roles of Ca2+ elevation and JNK activation in GF induced cell death, we applied Ca2+ chelator BAPTA-AM and JNK inhibitor SP600125 on PC3 cells upon GF treatment.

To evaluate the functional role of TRPV4 in the endothelium, we performed pressure myograph experiments in CA from WT and TRPV4−/− mice.

To evaluate the functional role of NIX in MALM, we prepared NIX-knockdown cells using A549 and LS174T (A549 NIX-KD and LS174T NIX-KD, respectiveLS174T NIX-KD3).

To evaluate the functional role of Oct4 in t-hPSCs, we stably knocked down Oct4 by shRNA and then isolated fractions based on green fluorescent protein (GFP) (Figure S2).

In the absence of an agreed upon model to evaluate the functional role of these observed changes we propose that behavioral experiments comparing the localization performance of bats with an intact noseleaf and a deformed one e.g., lancet bent backwards, should be performed to verify whether the changes in the spatial sensitivity due to the lancet in M. microtis are behaviorally relevant.

To characterize and evaluate the functional role of naturally occurring polymorphisms of the Lim3 5'-regulatory region, we first analyzed initiation of Lim3A transcription and determined the exact border between the regulatory and structural parts of the gene, and outlined proximal promoter region and potential binding sites for regulatory proteins within the regulatory region.

To evaluate the functional role of Notch signalling in rosette cultures, its activity was inhibited by treatment with the γ-secretase inhibitor LY411575 [25], resulting in a strong reduction of hes5 expression and the concomitant increase in Dll1 and hes6 expression (Fig. 2B, right panels).

This study aims to evaluate the functional role of SMC1A in colorectal cancer (CRC) both in vitro and in vivo, and the underlying molecular mechanisms.