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To evaluate the dose dependence of the pharmacokinetic behavior of sirolimus, AUC0 ∞ and half-life were calculated using a noncompartmental pharmacokinetic analysis implemented in the PK Solutions software (version 2.0; Summit Research Services, Montrose, CO).
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We evaluated the dose dependence of DBP-induced germ cell aggregation at E21.5 and found that aggregation was induced by exposure to DBP at all doses of ≥ 20 mg/kg.
To evaluate the dose and time dependence of paclitaxel-induced apoptosis in MCF-7 cells, cells were examined after 48 h treatment with increasing doses of paclitaxel 0-1000 nM) using Annexin V staining.
One-way ANOVA test confirmed the dose dependence of the OTM value (p < 0.001).
We initially examined the dose dependence of the liver toxicity of nanoclay particles.
However, the dose dependence and amplitude of these transcript levels differed in response to FSHβα, FSHβboCTPα and FSHβCTPα.
The dose dependence inhibition curve was assayed with 0.5, 0.05, 0.005 and 0.0005 mM phloretin.
The longitudinal dose dependence of the interferon anti-viral effectiveness observed here corroborates the dose dependence of interferon effectiveness previously described only cross-sectionally [ 5].
However, the study that best demonstrates the dose dependence is that of Bhasin et al (2005).
We therefore used this expression system to determine the dose dependence of the assay.
This study was designed to evaluate the time and dose dependence for efficacy of the most important nitroheterocyclic drugs in use for Chagas disease.
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