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It was not powered to evaluate superiority or long term outcomes including death.
While there is limited evidence that MBSR is effective in low back pain, more research is needed to evaluate superiority or inferiority of MBSR to other active treatments.
At 18 weeks an interim analysis on a subset of 253 patients was planned to evaluate superiority of efficacy of pramipexole ER to placebo on the Unified Parkinson's Disease Rating Scale (UPDRS) II + III (primary endpoint).
The primary objective is to evaluate superiority of the proposed HLA matching strategy in comparison to random graft assignment with respect to the primary endpoint 'time to first endothelial graft rejection'.
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156 157 158 Since fewer participants are receiving the full intervention as intended, non-adherence can reduce the contrast between study groups leading to decreased study power and increased costs associated with recruiting larger sample sizes for evaluating superiority, or leading to potentially inappropriate conclusions of non-inferiority or equivalence.
Here we outline the PARADIGM study (NCT02394795), designed to evaluate the superiority of panitumumab over bevacizumab, in combination with oxaliplatin/5-fluorouracil/leucovorin (mFOLFOX6) in patients with RAS wild-type chemotherapy-naïve mCRC.
The feasibility of the proposed resilient virtual flux-based DPC (RVF-DPC) is verified by using MATLAB/Simulink and a comparative study is conducted to evaluate the superiority of the proposed controller with another three representative table-based DPC schemes.
Based on this difference, it is therefore important to evaluate ultimate superiority of one over the other in lateritic soil stabilization.
To evaluate the superiority of switching retrieval modes, it is compared with the random caching strategy (R-Caching) in terms of RTT and the number of interest packets.
However, a randomized controlled study is necessary to evaluate the superiority of DCGEM to gemcitabine monotherapy.
Such a trial could also be designed to evaluate the superiority of active comparators.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com