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The aim of our study was to systematically review the growing body of published literature reporting on one specific multiple sclerosis (MS) treatment, fingolimod, in the real world to assess its effectiveness in patients with MS, evaluate methodologies used to investigate MS in clinical practice, and describe the evidence gaps for MS as exemplified by fingolimod.
This is because traditional regulatory processes are usually geared to assess products that aim to treat disease after they emerge, rather than evaluate methodologies that can help prevent and manage such age-relate diseases from occurring at the first place.
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This review is part of a series of reviews on behalf of the Prevention of Falls Network Europe (ProFaNE) which evaluate methodology in RCTs of fall prevention interventions in older adults.
Our main objective was to propose and evaluate methodology that takes advantage of any potential sparsity in the inverse of A22 in order to reduce the computing time required for its inversion.
Roundtable discussion on developing user requirements, human-centered design principles, and testing and evaluating methodologies.
In this study, we developed and evaluated methodologies for quantifying aboveground carbon (AGC) stocks affected by mountain pine beetle using field observations, lidar data, and multispectral imagery.
Today, researchers are evaluating methodologies for determining which patients should receive generalized care vs. specialized care, while others continue to study further treatment adaptations for patients with complex dual diagnoses.
Evaluation results indicate that the evaluated methodology achieves a level of accuracy higher than 96% (with TPR above 0.95 and FPR approximately 0.1), which slightly improves the results in previous studies that use byte n-gram representation.
Here we followed previously evaluated methodology described in detail elsewhere (Mah et al., 2012), implemented in SPM8 (http://www.fil.ion.ucl.ac.uk/spm/software/spm8/) and custom MATLAB (http://www.mathworks.co.uk/products/matlab/) scripts.
Four experimental tests were performed to evaluate the methodologies, applying two damage intensities.
Investors should continuously evaluate their methodologies and consider the most innovative ways to manage the renewal process to bump rents and minimize vacancies.
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