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5-Fluorouracil is a good candidate to evaluate in combination with docetaxel, since both agents are effective against metastatic breast cancer, but have different mechanisms of action and tolerability profiles.
It is an interesting drug to evaluate in combination with TNF because incubation of tumour cells with actinomycin D has been shown to increase their sensitivity to the effects of TNF (Alexander et al, 1987).
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Rapamycin analogs are sufficiently tolerable to be evaluated in combination with other agents, and are presently the only agents one can feasibly combine with emerging BRAF or MEK inhibitors.
This approach is being evaluated in combination with other NK-targeted therapies in preclinical testing, and shows considerable promise.
SVP[Rapa] is currently being evaluated in combination with pegsiticase in an ongoing multi-dose phase 2 clinical trial (Clinicaltrials.gov NCT02959918 22.
The performance of this system was evaluated in combination with a commercial fiber optic oxygen sensor.
Efficacy of a 'STimulator of INterferon Genes' agonist was evaluated in combination with carboplatin chemotherapy and PD-1 immune checkpoint blockade therapy in the ID8-Trp53−/− immunocompetent murine model of HGSC.
In this study, the PARP inhibitor ABT-888 was evaluated in combination with and compared to current standard-of-care in a genetically engineered mouse GBM model.
Response time during service recovery is evaluated in combination with the compensation provided by the firm and criticality of the service experience.
Over the years, the MCAT has gone through four major revisions and has only strengthened its ability to predict success in medical school, particularly when evaluated in combination with grades.
As a first-line treatment for metastatic disease, fulvestrant is currently being evaluated in combination with anastrozole versus anastrozole alone in 2 phase III trials, 1 by the Southwest Oncology Group and the other being conducted mainly in Scandinavia.
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