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However, many problems remain to be solved: controlled studies are necessary to evaluate clearly the benefit of this new therapeutic approach, and standardised criteria will be necessary (extension degree of surgical resection, type and dose of anticancer drugs, effect of higher intrapleural temperature, etc).
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Conversely, the oil-in-water-based adjuvant we evaluated clearly shifted responses towards a type-2 cellular immune response, dominated by IL-5 (and IL-10), results consistent with other studies evaluating oil-in-water-based adjuvants, including MF59™ [26].
It suggests that health providers do not place emphasis on evaluating clearly patients' nutritional status.
However, our strategy of examining white matter under each Brodmann area has the advantage of evaluating clearly adjacent position and extending into areas contiguous with the ventricles.
Although PChE activity is used to monitor the liver dysfunction and neurotxicity in humans exposed to several toxic chemicals, the enzymatic activity has not yet been evaluated clearly in the population chronically exposed to arsenic.
For each phase of biomarker development, it is important to customize the study design, statistical analysis, and sample size calculation, in order to evaluate the clearly defined research objective.
It will be fascinating to follow these cohorts of well-characterized children into adulthood, to evaluate more clearly the relative importance of preterm, infant and adult infectious exposure to the functioning of the immune system.
Finally, our findings should be considered hypothesis generating and encourage new prospective clinical research to evaluate and clearly define the role of oral nutritional supplementation and dietetic counseling in patients undergoing radiotherapy [28].
However, starting in the 1970s, the role of expert reviews began to be questioned for a number of reasons (e.g., potential bias of experts, timeliness of information); this led to the development of systematic approaches that would use rigorous, transparent, and explicit methodology to evaluate a clearly formulated question.
From there, explicit approaches that harness expertise to a rigorous, transparent, and systematic methodology to evaluate a clearly formulated question were advanced, and are now embodied in prominent empirically demonstrated methods such as the Cochrane Collaboration (Higgins and Green 2011) and Grading of Recommendations Assessment, Development and Evaluation (GRADE) (Guyatt et al. 2008b).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com