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This is because if we can understand how the drug blocks the channel and how mutations evade the effect of the drug, we can come up with better approaches to block it [20].
This mechanism may evade the effect of multidrug resistance proteins, present in cancer cells [ 17, 18].
If a sizeable proportion of infections in vivo occur this way, the virus may be able to avoid antibody effects, which mostly affect free virus, and thus evade the effect of the humoral immune response.
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It is not the host that evolves but rather it is the virus itself that can alter its molecular composition to evade the effects of the drugs making them ineffective.
Furthermore the pathogen itself could evolve mechanisms to evade the effects of the linked refractory genes.
The failure of current therapies to eradicate breast cancer is hypothesized to be due to the existence of a subpopulation of cells that can evade the effects of these treatments.
While EMT has been widely studied for its role in early development and, more recently, cancer metastasis, it may also contribute to a cellular ability to evade the effects of platinum-based therapies.
Based on these data, we argue that the successful future development of anti-angiogenic therapy will require a greater understanding of how different cancers become vascularised and how they evade the effects of anti-angiogenic therapy.
LSDV does not have a homolog of the A41L gene; there must be other mechanisms that mammalian poxviruses have evolved to evade the effects of CCL21, which is clearly important for the host in clearing poxvirus infection.
There is also evidence to suggest that it is the CSC population that mediates metastases and can evade the effects of chemotherapy and radiation therapy thus promoting recurrence and relapse [ 15– 22].
This solution evades the effect of financing decisions, and thus alleviates the non-exogeneity tax status of companies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com