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Dr. Dan Landau has received a New Innovator Award from the National Institutes of Health for his research on how tumor cells evolve and acquire new mutations to evade cancer therapies.
Dr. Dan Landau, an assistant professor of medicine and of physiology and biophysics at Weill Cornell Medicine and a core member of the New York Genome Center, has received a New Innovator Award from the National Institutes of Health for his research on how tumor cells evolve and acquire new mutations to evade cancer therapies.
As tumors typically evade cancer treatment by acquiring secondary mutations on targeted proteins, it appears more difficult for a tumor to escape from miRNA effects, which are directed on multiple proteins at the same time.
A major clinical problem is thus the ability of malignant cells to evade cancer drugs, either by altering expression of surveillance molecules or by upregulating signaling pathways capable of promoting cell survival and proliferation, even in the presence of an apoptosis-inducing agent.
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Then, the cells are modified so that they target the patient's immune-system evading cancer.
In addition, it was found to be expressed in tumor cells where it may play a role in evading anti cancer immune response [ 11].
Studies in the past years have evidenced that microRNAs (miRNAs) are critical players in the regulation of various biological functions, including apoptosis, which is a process frequently evaded in cancer progression.
The dynamic and reciprocal interaction between stromal and malignant epithelial cells has a profound impact on tumour progression in vivo, and as stromal cells are less likely to acquire de novo mutations, evade anti-cancer immunity or develop drug resistance, the development of targeted therapies based on improved molecular characterisation of CRC stroma is an attractive prospect.
AZD9291 targets a genetic mutation that helps tumours evade current lung cancer pills.
This phosphoramidate chemistry approach is the key to the ProTide technology and each new molecule is specifically designed to evade or overcome cancer resistance mechanisms in the uptake, activation and breakdown of nucleoside analogs.
Sharpe's research has yielded key insights into how cancer evades immune surveillance and thwarts the body's immune defenses.
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