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Second, not all children with aseptic meningitis had a specific infectious etiology identified.
Among the subgroup of ARDS with no risk factor, 45 (19.2%) patients eventually had an etiology for ARDS (Table 3), allowing for a targeted management, while 189 (80.8%) had no etiology identified during ICU stay.
Patients comprised adults ≥18 years of age with moderately severe falciparum malaria (MSM) defined as fever or history of fever in the past 48 hours, with >1000 asexual P. falciparum parasites/µL (a threshold for clinical falciparum malaria in Papua [20]), with no other etiology identified, requiring inpatient parenteral therapy because of inability to tolerate oral therapy.
Screening for RNF5 expression in muscle biopsies from patients suffering from muscular disorders including classical myopathies such as Duchenne and Becker myopathy as well as other myopathies with unknown etiology identified upregulation and mislocalization of RNF5 to aggregates in muscles from sIBM patients, as well as in a mouse model for hereditary IBM.
Patients with a genetic etiology identified in previously reported and unreported screens were excluded.
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease with no definite etiology identified and no effective treatment.
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Thus, it is of great value to better understand the etiology, identify valuable diagnostic and prognostic markers, and explore novel therapeutic strategies for this deadly disease.
Regardless of etiology, identifying low CoQ10 levels in patients with septic shock is significant, as the compound is essential to mitochondrial function and may play an important role in the pathophysiology of mitochondrial dysfunction in sepsis.
The generally poor survival associated with small cell carcinoma underscores the importance of understanding disease etiology, identifying prevention/screening modalities, considering new treatment approaches, and ensuring that older patients and racially/ethnically diverse populations are included in clinical trials of new agents.
The etiologies identified in the After group are described in Table 2.
The etiologies identified in the After group are described in Table 2.
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