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Several studies have suggested an etiological role for hypercholesterolemia in the pathogenesis of breast cancer and prostate cancer (PCa).
Mounting evidence in humans supports an etiological role for the microbiota in inflammatory atherosclerosis.
If this is replicated it would be consistent with an etiological role for increased IL1B expression in gout.
Nonetheless, recent observations from GWAS have suggested an important etiological role for pleiotropic genes/proteins [ 4, 6- 8, 39].
Unequivocal establishment of an etiological role for AAT deficiency, especially of intermediate degree, has proven to be difficult.
Of the biological hypotheses, the monoamine hypothesis proposes an important etiological role for serotoninergic or noradrenergic dysfunction in depression [ 4].
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However, despite the diversity among these outcomes there is reasonable evidence of etiological roles for estrogen.
Although the small number of A−β− KPD patients in this analysis made statistical comparisons unreliable despite the apparent difference in allele frequencies, several observations suggest possible etiological roles for these six variants.
In contrast, diabetes may not only moderate, but also mediate the association between obesity and physical HRQL (similar to abdominal obesity), not least because the etiological role of (abdominal) obesity for diabetes is more clear-cut than for depressed mood [ 13, 14, 20, 21, 28].
Infection with this organism is widespread, including Sri Lanka [ 2- 4] and epidemiological studies have clearly demonstrated a major etiological role of H. pylori for peptic ulcer disease, gastric MALT [mucosal associated lymphoid tissues] lymphoma, and distal gastric cancer [ 5, 6].
Our study shows that dietary modulation of the gut microbiota contributes to the alleviation of metabolic deteriorations in both PWS and SO cohorts, suggesting a common etiological role of dysbiotic microbiota for disease progression, regardless whether the obesity is genetically predisposed or simply diet-induced.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com