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The etiologic microorganisms of APN are shown in Table 2.
However, evaluation is complicated by the heterogeneity of clinical manifestations, sites of infection, comorbid conditions, and etiologic microorganisms [ 6].
The spectrum of etiologic microorganisms is presented in Table 2. Streptococcus pneumoniae was the most common pathogenic organism.
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The same group reported that M. avium (49%) following rapidly growing mycobacteria (19%) were the most common etiologic microorganism in anti-TNF α receivers [ 40].
However, rapid and accurate diagnosis methods (e.g. PCR assays) should be employed to identify the etiologic microorganism and help adapt antibiotic therapy for such infections.
The underlying pathogenesis of sepsis is complex and dependent on the etiologic microorganism, site of infection, and host factors (1, 2).
Luna and colleagues [ 89] demonstrated that the positive predictive value of blood cultures to detect the etiologic microorganism was 73% and the sensitivity of blood cultures was only 26%.
Indeed, 25% of our etiologic diagnoses correspond to microorganisms for which the diagnosis is usually based on serologic testing.
One kind of etiologic factor linked to membrane rupture was microorganism infection and maternal or fetal host inflammatory response [ 5].
Although the cause of sarcoidosis remains unknown, several microorganisms have been proposed as possible etiologic agents, including bacteria (Borrelia burgdorferi, Proprionibacterium acnes, and Mycobacterium species) and viruses (Human herpesvirus 8, Epstein-Barr virus, Cytomegalovirus, and Coxsackie B) (2).
Microorganisms organized in the subgingival biofilm are the primary etiologic agents in PD.
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