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The latter estimates are the preferred measure of association in etiologic analysis (27)—the major focus of our study.
The cohort used for the present etiologic analysis included all patients who received first-line chemotherapy with fluoropyrimidine and oxaliplatin or irinotecan, without additional targeted agents.
However, based on the R package developed [ 19], it is worth investigating the robustness of any descriptive or etiologic analysis under plausible scenarios for MNAR data.
Second, although the AHEAD is rich in self-reported data and linked to Medicare claims for more than a decade, detailed clinical histories were not available, restricting our study to an epidemiologic vs. etiologic analysis.
Even though these methods are not considered appropriate for etiologic analysis (27), which is the purpose of our analysis, competing risk analysis can provide additional valuable information for risk prediction (27).
Trend analysis is one leg of this analytic triangle, and is used for public health surveillance and monitoring, for forecasting, for program evaluation, for policy analysis, and for etiologic analysis, investigation of potentially causal relationships between risk factors and outcomes [ 4].
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Thus, research projects can be classified as etiologic, interventional, policy analysis, health service, theoretical, methodological or healthcare system studies [ 29].
For etiologic research, ideally the analysis will be based on individual-level data.
Based on the reactivity of amebas in tissue sections with anti– Naegleria fowleri serum in indirect immunofluorescent (IIF) analysis, the etiologic agent was identified as N. fowleri.
Our study is a demonstration of a novel analysis of etiologic heterogeneity taking advantage of the abundant genomic resources available from the TCGA project.
The reversal of etiologic time during re-analysis of traditional cohort data then leads to a situation where the exposure data become left-censored instead of right-censored.
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