Departments and institutions have the same problem as individual investigators: They want money to be available where it is needed, and they struggle to ethically and legally move targeted funds into discretionary accounts to meet the realities of research.
Moreover, the emergence of the precision medicine resulting from the research of a couple of predictive biomarker / targeted therapy made ethically difficult to continue RCTs in this situation and allowed to the development of new therapeutic trial study design such as stratified trials, basket and umbrella trials, adaptive and finally molecular algorithm trials.
Control of BG to achieve a clinically and ethically approved target remains a crucial element in the treatment of intensive care unit (ICU) patients and necessitates the design and assessment of measures that reflect this level of control.
On the basis of the thresholds of toxicological concern (TTCs) set for food additives and on the opinions of Dutch drinking water experts of what is ethically acceptable, target values of 0.01 μg/l for genotoxic contaminants and 0.1 μg/l for other contaminants have been derived [ 1, 72, 79].
"We are a team of libertarian cocaine dealers," writes one dealer, targeting the ethically conscious user: "We never buy coke from cartels!
To target more ethically aware consumers, companies should adequately incorporate their CSR activities in their marketing communications.
"Had Rolling Stone done the fact-checking and digging that they were legally and ethically required to do as journalists, dean Eramo would not have been so wrongfully targeted".
"They are normal people who are living their daily lives, and targeting them is a condemned act ethically and politically".
Given this striking difference, it is debatable whether an RCT specifically targeting these difficult cases can be undertaken ethically.
The result is this play -- an on-target skewering of the ethically murky cesspool that is the new millennium sitz bath for some among corporate America's elite.
