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The responsible National Health Service (NHS) R&D Consortium stated that this study did not require ethical submission to an NHS research ethics committee as it represented an evaluation of part of an ongoing primary care trust (PCT) programme.
As strains were based on MRSA collections from previous epidemiological studies, no clinical data were obtained nor further ethical submission made.
RDP designed the study, completed ethical submission, consented patients for study, performed, analysed and interpreted gene expression profiling and immunohistochemistry and wrote the manuscript.
ECD - participated in study design, assisted with ethical submission, assisted with analysis and interpretation of gene expression and immunohistochemical data, and writing of manuscript.
APD was responsible for trial management, co-authored the protocol and ethical submission, had input into the data analyses, contributed to the interpretation of study data and wrote the paper.
SHR was Principle Investigator for the study, co-authored the protocol and ethical submission, had input into the data analyses, and contributed to the interpretation of study data and to revisions to the paper.
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Delaying ethics submission in order to meet targets would be particularly challenging for researchers as many funders only begin releasing grant awards on receipt of ethical approval.
The registry was piloted in six centres and following further fine tuning of the data sets, ethical committee submission and approval was completed.
Ethical Considerations: a submission was made to the University of Wollongong's Human Research Ethics Committee HRECC- HE08/142) in which all university Heads of Schools, participant groups, research areas and methods were listed.
PIRg members reviewed all the study support materials (information sheets and topic guides) prior to their submission for ethical review to ensure that information was accessible and unambiguous.
Our institution, the Oxford University Hospitals National Health Service Trust, classifies our work as a service evaluation and therefore did not require a submission for ethical review.
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