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Three of the constituent groups the academic clinicians, other stakeholders, and academic biostatisticians rated disadvantages of ACTs from a societal perspective in a range of possibly to probably not disadvantageous, whereas the consultant biostatisticians rated ACTs as definitely not having ethical disadvantages from this perspective.
The participant groups identified potential risks and hence potential ethical disadvantages of ACTs.
All four constituent groups rated adaptive trials as having few potential ethical disadvantages when considered from the researcher's perspective.
Participants were asked to consider ethical advantages and potential ethical disadvantages from the perspective of patients, researchers and society.
On the other hand, the academic biostatisticians had some overlap with the academic clinicians and other stakeholders, but their anchor points deemphasized ethical advantages and emphasized ethical disadvantages.
More than the other groups, academic biostatisticians assessed the ethical disadvantages of ACTs for patients to be high; their VAS responses ranged from probable disadvantages to definite disadvantages.
Similar(53)
Logistical disadvantages, ethical constraints, costs and high execution times could have a negative impact on the execution of the clinical trial.
However, at an individual level, perspectives on the ethical advantages and disadvantages of ACTs varied considerably.
Survey and mini-focus group questions were formulated to gather opinions of the clinical trial experts regarding the ethical advantages and disadvantages of ACT designs.
Study instruments were developed by an ethicist (MF) and experts in both traditional and adaptive clinical trials (WM, RL), and focused on the evaluation of ethical advantages and disadvantages of adaptive clinical trial designs.
Regarding intergroup comparisons, the academic clinicians and other stakeholders had roughly similar patterns of rankings of the ethical advantages and disadvantages of ACTs from the participant, researcher, and societal perspectives.
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