Cytogenetic test is considered to be indicator of oxidative potential, genotoxicity, and estimation of the mutagen potency in meiotic PMCs and PGs [ 12, 19].
Lastly, joint (multivariate) modeling of the PD and vital sign variables would allow for better estimation of the relative potency and the therapeutic index.
Cytogenetic tests are considered to be indicator of cytotoxicity, genotoxicity, genetic variability, and estimation of the mutagen potency in meiotic PMCs and PGs [ 12, 19].
Deviations in the estimation of the estrogenic potency of the effluents by the CA model, compared with the measured responses in the rYES, are likely to have resulted from inaccuracies associated with the measurement of the chemicals in the extracts derived from the complex effluents.
Such parameters may be useful as quantitative estimates of the potency of hepatocarcinogenic agents not only in rodents, but potentially in quantitative risk estimations in the human.
The model fit resulted in the estimation of drug potency (IC50: 1.7μM), and systems parameters such as EPO mRNA turnover (kdeg_EPOmRNA: 0.43 hr-1) and mean lifespan of reticulocytes (T r: 81 hours).
The voltage protocol and temperature may affect the estimation of drug potency, but limited information is available in this regard.
We conclude that the additional terms which treat charge transfer, polarisation and dispersion effects during ligand binding in this QM method significantly improves the estimation of ligand potency compared to MM-based procedures.
For the estimation of the in vitro cytotoxic potency of the investigated extracts, an established microtiter plate assay [ 9] was used with three human cancer cell lines: one lung cancer (A-427), one urinary bladder cancer (5637) and one breast cancer (MCF-7) line.
Based on the above information, it is clear that HCB should be classified as a dioxinlike compound, that more studies are needed to reduce the uncertainty in the estimation of a relative potency value for HCB, and that epidemiological studies should be undertaken in infants fed breast milk in countries with high HCB exposure levels.
