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Exact(12)
The Wei, Lin and Weissfeld method allows the estimation of separate effects of the intervention on the hazard of the first event, second event, third event, etc., based on groups comparable at the point of randomization; because randomization is preserved in the estimation of the intervention effects for events beyond the first event, these estimates are valid.
This could, then, result in either under- or over estimation of the intervention effects [ 14, 15].
The estimation of the intervention effect was performed according to the intention-to-treat principle.
This resulted in de most 'conservative' estimation of the intervention effect.
The result from a mixed model analysis presents a more accurate estimation of the intervention and standard errors [ 41].
The addition of a third level added complexity to the model and only changed the estimation of the intervention effect by 2 percentage points.
Similar(48)
If the anticipated intervention effects are clearly defined in a published review protocol, and if pre-defined sensitivity analyses assess the uncertainty of the estimation of the anticipated intervention effects, then many of the problems with using anticipated intervention effect will be limited.
To make the estimation of the anticipated intervention effects as optimal and as objective as possible, we recommend, as one option, to base the estimation of the anticipated intervention effect on former randomised clinical trials.
The uncertainty of the estimation of the anticipated intervention effect is a challenge and a major limitation – but remains a necessary evil.
First, this is an exploratory trial and the sample size is small leading to imprecision in estimation of some of the intervention effects.
Coefficient β e in the regression model 1 and 2 is actually an estimation of the interaction between intervention and time, measuring the DID.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com