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With our analysis we hope to contribute to the ongoing discussion on the decision of implementing routine rotavirus vaccination in the Netherlands taking into account estimation of the incremental cost-effectiveness ratio (ICER) play an important role in this discussion.
We used cost effectiveness acceptability curves to represent the uncertainty in the estimation of the incremental cost effectiveness ratio.
Cost-effectiveness analysis involves estimation of the incremental cost of a new intervention as well as its incremental net health benefit, in comparison with a reference.
Analysis of uncertainty in the joint estimation of the incremental cost-effectiveness ratio is illustrated via cost-effectiveness planes (via bootstrapping with 5000 replications).
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32 Within each risk-defined subgroup, the analytic comparison focused on the joint estimation of incremental costs and incremental QALYs (with increments calculated as the intervention group value minus the control group value).
In this case, there are degrees of freedom in the flux estimation when applying the incremental estimation approach.
This difference will then be divided by the subtracted effects (case of response or remission on the BAI) and an estimation of the bCBT treatment groups' incremental costs in relation to their incremental health benefit will be generated.
Because of the high degree of non-linearity in the estimation of the knot locations, an incremental knot insertion algorithm is proposed.
This is because full economic evaluation involves estimation of the joint distribution of incremental costs and effects (cost-effectiveness) accruing from an intervention, compared to relevant alternatives, for specific populations, jurisdictions, or settings.
Henceforth, we refer the aforementioned estimation method as the incremental parameter estimation (IPE).
Subsequently, as suggested in the literature [ 23, 24], cost against health benefit was explored through the estimation of Incremental Cost-Effectiveness Ratio (ICER), described as the difference in mean costs divided by the difference in mean QALYs between two interventions.
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