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Estimation of the endpoints was made after 48 h.
These facts gave us a better estimation of the endpoints, and also added statistical power to the analyses.
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The GEE model presented, in conjunction with the test for appropriateness of the model, form the basis for an adaptive analysis approach for determining the method of estimation of the primary endpoint.
The sample size (n = 45) was calculated to allow the estimation of the primary endpoint with sufficiently narrow confidence intervals to inform further development.
In order to take into account, that drop outs (see definition non compliers) could falsify the estimation of the primary endpoint 'failure' sensitivity analysis will be done.
This conclusion, as highlighted also for the estimation of transmission endpoints in LF [5], signifies the need for collecting more reliable standardized data spanning the natural range of prevalences observed in the field at the regional level.
Forty-one patients were registered to allow reliable estimations of the primary endpoint for patients receiving alemtuzumab and to estimate e.g., the complete remission rate for patients with alemtuzumab with a precision of ±18%%.
Radiotracer design, the properties of the molecular targets which can be studied and the quantitative estimation of pharmacological endpoints will be discussed in relation to these applications, with particular reference to studies in brain.
For the sample size estimation of both endpoints an α=0.025 is assumed in order to adjust for multiple testing.
Estimation of the incidences of the primary endpoints was accurate in the control group (i.e. in the CTG-alone group) only in the Swedish RCT (metabolic acidosis) and in the Plymouth RCT (operative delivery for fetal distress, ODFD).
These include inter-assessment intervals, which is pertinent as longer periods can result in cruder estimation of some endpoints such as TTP (Cassidy, 2000).
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