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GFR equations may facilitate the estimation of kidney function in older patients.
The use of the Grubb equation makes sense in this case, as it is resulting in a more conservative estimation of kidney function.
Equations have been proposed in order to provide the physician an easy way of calculation and an accurate estimation of kidney function (Table 2).
Estimation of kidney function in critically ill patients with acute kidney injury (AKI), is important for appropriate dosing of drugs and adjustment of therapeutic strategies, but challenging due to fluctuations in kidney function, creatinine metabolism and fluid balance.
The Cockcroft-Gault (CG) equation and the four-variable Modification of Diet in Renal Disease (MDRD) formula are the most commonly used methods to provide estimation of kidney function.
However, in the absence of patient data such as height and weight, estimation of kidney function by established equations becomes less accurate for individuals below 18 years of age, and we did not consider them in our analyses.
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We found that cystatin C-based equations resulted in more optimistic estimations of kidney function than the creatinine-based ones.
The CG equation resulted in the lowest and the Perkins equation in the highest estimation of kidney-function.
This likely also explains the significant declines in eGFR prior to detection and further emphasizes the need to use GFR estimation in the monitoring of kidney function.
Furthermore, serum levels of cystatin C were used to estimate GFR; this method is considered to be a more reliable indicator of kidney function than estimation via creatinine-based GFR, particularly in the elderly (24).
Moreover, this method has been recommended as the reference approach for determination of GFR by the Nephrology Committee of Society of Nuclear Medicine [ 25], and is widely used as a standard method for evaluation of kidney function and estimation of GFR in China.
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