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Quantitative evaluation results indicate that the normalized ASTM offset method is very promising as a precise, simple and practical Kop determination method alternative to the ASTM method, and also the use of the 2/PI (ΔKeff) estimation method is recommended.
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For these reasons, the brain slice method is recommended for estimation of target-site pharmacokinetics in the early drug discovery process and fundamental pharmacological studies.
In this case, the diagonalized-implicit method is recommended.
Triangulation of various assessment methods is recommended.
Hence, establishing feasible control methods is recommended.
Anchor based methods were recommended as primary methods for MCID estimation complemented by various distribution-based estimates (e.g., ES and SEM) as supportive information [ 25, 36, 37].
Two simple marching methods are recommended for non-azeotropic systems.
Hybrid techniques combining the advantages of different methods are recommended.
These newly developed methods are recommended for further application.
Further interventions using rigorous methods are recommended.
# confidence estimation method is run.
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