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The results are summarized narratively with 95% confidence intervals (CIs) for estimates where possible.
We used the generic inverse variance method to pool effect estimates, where possible.
For observational studies (cohort, case-control, cross-sectional, case series) we presented effect estimates where possible as percentages, RR or odds ratios (OR) with 95% CIs, adjusted RR or OR if reported with 95% CIs, or P-values only, in tabular format based on study type; we used narrative synthesis to summarise the studies.
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The cost of treatment not routinely incurred was estimated, where possible, for individual patients.
The gels were treated as blocks in a linear model, so that effects were estimated within gels where possible.
We plan to use the practice computer systems to provide an estimate of this, where possible.
We used estimates of drug costs where possible but did not make a more detailed estimate of the costs of the different interventions.
Our analysis is based on the results of an extensive literature search, using estimates from systematic reviews where possible.
Response rates and where possible estimates of resource use were compared across the three methods i.e. telephone questionnaire, diary and patient records.
In estimating the cost we have only used the rough estimate of drug costs where possible, in addition the local service planners could take into account the actual cost involved in providing the services such as cost of investigations and for the staff, and in particular the on-going costs of long-term treatment and clinical care.
Finally, the sample estimates were compared with estimates obtained from other sources where possible.
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