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Weighting of the pooled estimates was performed with the random effects model since it was expected that one or more non-RCTs would be included in the analysis [27],[28] and because this model takes into account the heterogeneity of the data [27].
Thus, uncertainty analysis on the incidence estimates was performed as follows.
The calculation of combined estimates was performed using the Mantel-Haenszel method.
The adjustment of relative survival estimates was performed as described by Brenner and Hakulinen (2003).
The statistical significance of differences between ROC estimates was performed applying the method by Hanley and McNeil (1982).
Exploratory iterated principal components factor analysis with squared multiple correlations as initial communality estimates was performed to examine dimensionality.
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Random forest code was written in Java for this study, and all statistical analyses (e.g., model performance estimates) were performed using R.
All analyses were performed using SAS® PROC MIXED [ 7] with Maximum Likelihood estimation, and tests of parameter estimates were performed using likelihood ratio tests.
All statistical analyses and ROC estimates were performed using Splus (Version 6.1, Insightful Corp., Seattle, WA).
To improve the quality of the matches, estimates are performed imposing the common support condition in the estimation of the propensity score.
The estimates were performed with the help of Stata's class of - mi estimate - commands.
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