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Several sensitivity analyses have been undertaken on these central estimates to consider uncertainty.
The LD values in the core collection are, however, again conservative and are actually the appropriate estimates to consider for the definition of the window size around the significant SNPs in the core collections.
We have basically two sets of estimates to consider: the estimates for the failing Browne et al. [ 1] two-factor model, and the estimates for the fitting progressive measurement interference model.
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The sample size has been estimated to consider all the variables, assuming an alpha value of 0.05, powered at 80% in all of them.
This may be optimistic due to the potential for overfitting, because it has been suggested that there should be at least 10 events (deaths) for each variable to be estimated in order for parameter estimates to be considered reliable [ 33].
Several attempts were made to estimate a threshold to consider a gene as being active.
However, it should be noted that these estimates should be used to consider trends over the long term rather than giving precise year-on-year estimates.
Since the process is nonlinear we have to consider estimates that are not normally distributed.
To get the best estimate, we would have to consider all codings.
It also could be insightful to consider estimating diversity using established indices (e.g., Shannon, Simpson), which could help relate your work to other similar studies.
Then there's the costs of marketing the opportunity to potential franchisees to consider; she estimates it costs around £5,000 per franchisee to recruit.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com