In sparse data situations with unusual curvature in the underlying function, nonparametric techniques often result in estimates with problematic variation whereas their parametric counterparts may result in estimates with problematic bias.
Pan and core genome size estimates are problematic because they depend on the estimation of the occurrence of rare genes and genomes, respectively, which are difficult to estimate precisely because they are rare.
Similarly, if a grandparent's illness precedes their death, IV estimates are problematic because young mothers might have to change their labor force participation status to help out regardless of grandparental childcare availability.
To judge whether τ i estimates are problematic, one may develop a sampling based method (see Supplementary Material S2).
Detection and quantification of augmented renal clearance by estimates is problematic, and should rather rely on CLCR.
Collecting representative data on sensitive issues, especially data that are used to determine population prevalence estimates, is problematic whatever mode of data collection is employed [ 2- 6].
All of these estimates are problematic and must be considered tentative because some suggest ages that are likely too old (e.g. [ 9]) and others find the family to be younger (e.g. [ 57]) or barely older than its own crown-lineage fossils (e.g. [ 57]).
The GHG emissions of a product throughout its life cycle must be estimated, with problematic parts and/or materials identified to reduce greenhouse gas (GHG) emissions by the product.
Finally, we do not report on the calories delivered to patients by means of CRRT because its estimate is problematic.
We have deleted the Van't Hoff plots because we agree that the precision of the occupancy estimate is problematic and can potentially be obscured with increasing B-factors.
