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Biokinetic models of metal accumulation currently lack estimates of uptake from deposit vs suspension feeding.
As might be expected, the resource requirements and health gains attainable with screening were highly dependent on estimates of uptake.
Programme cost-effectiveness was based on an assumed uptake of 75% but current estimates of uptake in primary care are less than 50%.
We decided to derive our base-case value from the large UK Flexible Sigmoidoscopy Trial [ 38] to provide some consistency with the source of the estimates of uptake for the faecal tests.
COVER data was only used to check that our assumptions regarding age-dependent attendance and bad experiences led to plausible estimates of uptake at 1 year, 2 years and 5 years.
Two national studies have reported estimates of uptake of the HPV vaccine among adolescent males approximately one year after it was first approved and permissively recommended for males., One of these studies reported on an online survey of a national sample of parents of 11 17 y old males selected through a dual frame approach (random-digit dialing supplemented by address-based sampling).
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The rough estimate of uptake was 34% based on distribution of about 1,000 leaflets and assuming one leaflet per patient.
The investigation provides an estimate of uptake for a very low-cost promotion of a cessation intervention that can be used without health professional instruction.
In order to deliver a reliable economic evaluation, an accurate estimate of uptake of NIPT and the effect of introducing NIPT on the uptake of both DSS and any subsequent IPD is required.
Our estimate of uptake from inhalation is based on indoor air concentrations of ∑DDT (in this case consisting mainly of DDT) that were measured over a period of 240 days after a spraying event in both the gas and the particulate phase separately (Singh et al. 1992).
Conversely, the collection of end-exhaled breath concentrations provides an integrated estimate of uptake via both inhalation and dermal contact (Egeghy et al. 2003; Pleil et al. 2000) but cannot determine the relative contributions of the two exposure routes to the internal dose.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com