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Under these test conditions, the use of the "cone-tainer" method provided estimates of toxicity consistent with those from plants grown in assemblages, and potential interactions between plants were not found to modify the response of macrophytes to atrazine.
Efforts to refine the estimates of toxicity and/or exposure (WHO Tier 2 or 3 assessment), or to reduce exposures should focus on this primary chemical.
The remaining analytes in the mixtures contributed very little to the predicted toxicity of the mixture exposures and they can be assumed to be additive without significantly affecting the estimates of toxicity.
The increased cost is offset by the potential to obtain more realistic and generalizable estimates of toxicity response in the genetically diverse populations.
Unfortunately, this technique does not always provide accurate estimates of toxicity (Fernández et al. 2002) and requires considerable resources and time.
Our modeling and simulations of the CsA mediated ROS production gives biologists insight into mechanisms of toxicity and provide quantitative estimates of toxicity beyond the time and dose range used in experiments.
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The MBA is still the most reliable test for toxicity in shellfish because it provides an estimate of toxicity directly and can include more than one contaminant.
Peripheral AUC is used as an estimate of toxicity.
For instance, an estimate of toxicity values (IC50 or half minimal inhibitory concentration) for the intermediates p in the chassis organism, may be obtained either from experimental databases [ 47] or from structure-activity relationship models [ 48].
This issue is especially important when there are a large number of NDs that could drive the estimates of the toxicity of the mixture and the MCR values.
Therefore, chronic human health values were used in this assessment as conservative estimates of acute toxicity RVs.
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