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Phase 2 cancer chemoprevention trials are designed to provide estimates of the efficacy of an agent at a specified dose, and the expected size of the risk reduction that may be achieved in a subsequent phase 3 randomized trial.
The authors performed an updated meta-analysis of trials to obtain the best estimates of the efficacy and safety of levosimendan for the initial treatment of decompensated heart failure.
Many methods, including last observation carried forward, yield biased estimates of the efficacy or potency, especially with modeling.
Together, these obstacles prevent direct estimates of the efficacy of patient isolation in reducing transmission using routine surveillance data.
We reasoned that only experimental and quasi-experimental designs minimize the risk of confounding, and allow valid estimates of the efficacy of navigation.
Despite these caveats, we believe that this approach does provide reasonable estimates of the efficacy of 3- and 5-yearly (but not annual) screening (Table 5).
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In Beecher's study, this might have been missing, because the dispenser of the drug would have known that the drug might just be a sugar pill – so this 35% may be a conservative estimate of the efficacy of placebo.
This study aimed to provide both an initial estimate of the efficacy of the vaccines used in combination and to compare this with the single vaccine PEV3A.
In 2003, a randomized controlled Phase IIb proof-of-concept trial was conducted in Mozambique to provide a preliminary estimate of the efficacy, immunogenicity and safety of RTS,S/AS02A malaria vaccine in an age group (1 to 4 years) that would be close to the ultimate target population (infants) [4], [10].
The exploratory trial is a feasibility pilot study to establish a preliminary estimate of the efficacy of an innovative intervention.
The primary objective is to determine a population and individual patient estimate of the efficacy of MPH in alleviating fatigue with advanced cancer.
More suggestions(14)
estimates of the efficiency
assessments of the efficacy
predictions of the efficacy
estimates of the potency
estimates of the effect
calculations of the efficacy
estimates of the impact
estimation of the efficacy
estimates of the efficient
projection of the efficacy
estimates of the therapeutic
estimates of the cost effectiveness
estimates of the effective
estimates of the efficiencies
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com