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Estimates of cases occurring outside hospitals run as high as three million annually.
The study, by the Centers for Disease Control and Prevention in Atlanta, and published in The Journal of the American Medical Association, is the first time that the agency has searched historical records going back to 1900 to compile estimates of cases, hospitalizations and deaths for all the diseases children are routinely vaccinated against.
Ms Ewing says she absolutely recognises that the estimates of cases is "not an exact science" and that the government have "no way of knowing" the exact figures at this stage". The community safety and legal affairs minister says that the government have used a range of sources to reach this estimate and there has been no other way of doing this.
Our estimates of cases are larger, by about 10-fold, than those reported by Fraser et al. [11].
Recurrence of first episode of severe anaemia was observed in 10.2% (Kaplan-Meier estimates) of cases during the 18-month follow-up period, with a median time to event of 2.9 months (IQR 1.4 6.6) (Figure 3).
Annual absolute estimates of cases and deaths of cervical cancer were 62,000 and 30,000, respectively, in 2012 [1].
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The lack of a proper case definition and only approximate estimates of case numbers in this outbreak limit their value for estimating epidemiologic parameters such as reproduction number.
The challenge of implementing an effective childhood TB control has been complicated by poor estimates of case load and inadequate quality of data reporting the cases [ 1].
First, our estimates of case clustering are imprecise because of the limited number of MDR TB cases observed during the study period.
We used the estimates of case numbers and the demographic information gathered about deaths to calculate age specific case fatality rates.
However, estimates of case fatality ratio are useful comparative measures of severity across regions of the same country, pandemic waves, age groups, and patterns of neuraminidase inhibitor administration.
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