However, the estimated probabilities of achieving gains in BCVA at 1 month can be used to inform an economic model comparing ranibizumab with dexamethasone.
When analysed by the type of OAD, the estimated OR of achieving HbA1c target was significantly greater for the addition of basal insulin to baseline MET monotherapy versus MET + SU combination [0.738 0.218 to 1.2588), p = 0.005] or SU monotherapy [1.016 0.377 to 1.6566), p = 0.002].
For each of the four treatment response criteria, the estimated probability of achieving the endpoint at or before week 16 of atomoxetine treatment was at least 50%, and by week 20 it was at least 60%.
An indirect comparison of the efficacy of fingolimod and DMF or teriflunomide was performed by comparing the estimated RRs of achieving NEDA status for each treatment versus placebo using the Bucher et al. [ 33] method.
The model showed overall greater response to ranibizumab than to dexamethasone: the estimated probability of achieving ≥20 letters improvement from baseline in BCVA at month 1 was 0.191 in BRVO patients on ranibizumab and 0.093 on dexamethasone.
Second, the estimated RR of achieving NEDA status for DMF versus placebo in the pooled DEFINE and CONFIRM population was calculated using a fixed-effect inverse variance-weighted method of the RRs from each study, a standard method for pooling outcomes from studies that provides a weighted average of estimates.
Third, the estimated RR of achieving NEDA status for fingolimod versus placebo in the pooled FREEDOMS population (from the 'estimated' models) and the predicted RRs for fingolimod versus placebo in comparator trial populations (from the 'predicted' models) were compared with those calculated for DMF and teriflunomide in their respective trials.
The base case estimates for probability of achieving an improved HDDS or FCS outcome were taken from the LIG survey [ 20].
The fOR estimates the odds of achieving pregnancy in any given month, conditional on not having become pregnant in a previous cycle.
To examine factors that influenced average CPR in IIS and estimate prospective costs of achieving the Healthy People 2010 goals, a behavioral cost equation was estimated using weighted least squares with site-specific fixed effects.
An ordered logistic regression analysis was used to estimate the prediction of achieving radiologic progression.
