Pan and core genome size estimates are problematic because they depend on the estimation of the occurrence of rare genes and genomes, respectively, which are difficult to estimate precisely because they are rare.
Similarly, if a grandparent's illness precedes their death, IV estimates are problematic because young mothers might have to change their labor force participation status to help out regardless of grandparental childcare availability.
To judge whether τ i estimates are problematic, one may develop a sampling based method (see Supplementary Material S2).
All of these estimates are problematic and must be considered tentative because some suggest ages that are likely too old (e.g. [ 9]) and others find the family to be younger (e.g. [ 57]) or barely older than its own crown-lineage fossils (e.g. [ 57]).
Finally, we do not report on the calories delivered to patients by means of CRRT because its estimate is problematic.
We have deleted the Van't Hoff plots because we agree that the precision of the occupancy estimate is problematic and can potentially be obscured with increasing B-factors.
Estimating (38) is problematic as the self-employed are systematically misreporting their income and the income that is observed is an individual's transitory rather than permanent income.
As discussed below, the use of the Bayesian Information criterion (BIC) or the Akaike Information criterion for estimating clusters is problematic.
Estimating connectivity is problematic in marine species with long pelagic larval stages that have potential for long-distance dispersal (Roughgarden et al. 1988; Mora and Sale 2002).
