In a subgroup of eight studies with mixed post-treatment evaluations of one year (n = 6), six months (n = 1), and one month (n = 1), King's review produced a lower summary estimate of sensitivity (72%) in the subgroup of treated populations as compared with the overall analysis (81%).
The study conducted in children, Wansink 2003 (S1), comprised 96 participants and found a SMD of 2.31 (95% CI 1.79 to 2.83 - low quality evidence), whilst the estimated summary effect size in the subgroup of two studies conducted in adults, Wansink 2003 (S2) and Wansink 2005d, comprising 136 participants, was SMD 1.03 (95% CI 0.41 to 1.65 - low quality evidence).
Different MID estimates would likely be generated in the subgroup of patients with type 1 diabetes who experience frequent, recurrent episodes of severe hypoglycaemia.
The seemingly increasing risk estimates with longer duration of use in the subgroup of sequential formulations, for example, showed largely overlapping confidence intervals, as can also be seen for other trends with increasing duration of use.
There were too few non-Caucasian families to perform variance components linkage analysis separately, however, linkage analysis was repeated in the subgroup of families estimated to be Caucasian by Eigenstrat [ 15].
A subgroup analysis was performed in the subgroup of patients presenting to the ED without hypotension.
Despite statistically imprecise estimates in the subgroups, it raises a question about timing of metformin along the clinical course of critical illness.
The final step of the analysis was pooling accuracy estimates in homogeneous subgroups of studies with identical type of tumour and identical cut-off value.
Reliability (test retest) was estimated in a subgroup of 99 patients who completed the re-test after a mean of 13 days (5 30 days).
We also provide cost estimates in homogeneous subgroups of patients defined by patient characteristics and by the type of care received.
