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We systematically identified prospective studies detailing pain prevalence in definite MS. We used pooled prevalence estimates, explored heterogeneity using meta-regression, and analysed prevalence during the disease course using both estimates at disease milestones and longitudinal studies.
A summary estimate was constructed and heterogeneity of the estimates explored using meta-analysis (using inverse-variance and derSimonian and Laird method [ 28]).
Most of the detailed comparisons made between results from this dataset and comparable figures from various other sources of estimates, explored in the accompanying papers, showed a high degree of congruence.
For example, in the absence of DNA controls or simulations an empirical Bayes approach with a sliding value of bias could be used and the robustness of AI estimates explored across a range of likely values of bias.
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Figure 2 shows the avoidable deaths during follow-up estimated under the three explored hypothetical distributions of stage.
The open ocean is the largest and least explored environment on Earth, estimated to hold up to a million species that have yet to be described.
But finding new terrain to explore on a thoroughly explored globe is a tricky proposition.
The deep ocean is the least explored environment on Earth, and scientists estimate that many thousands of species are yet to be encountered.
Subsequently simple models for the genotype means estimated at the most probable QTL position were explored, as described in Hackett et al. (2014).
This study estimated adherence levels, investigated determinants for ART adherence and explored barriers and facilitators of adherence among children and teenagers in rural Tanzania.
Heterogeneity was further explored comparing model fit from meta-regressions, estimated through Bayesian [ 16] Markov chain Monte Carlo simulation [ 17] using WinBUGS version 1.4.3 (MRC Biostatistics Unit, Cambridge, UK) [ 18, 19].
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