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Of the disorders used in this study, all the affective disorders and all of the anxiety disorders except for post-traumatic stress disorder were included in the part one questionnaire, while the substance use disorders and post-traumatic stress disorder have been estimated using the part two sample.
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Age of onset and projected lifetime risk as of age 75 years were estimated using the two-part actuarial method implemented in SAS version 8.2.
The RBPF divides the state vector into two parts, one part, which is estimated using the PF, and another part, where KFs are used.
Lifetime costs and outcomes were estimated using the same two-part decision-analytical model used in the previous PLATO cost effectiveness analysis.
Multi-Response Permutation Procedures (MRPP) statistics were estimated using the mrpp and meandist functions, part of the R-package vegan [12].
We based the measure of relative evolutionary rate on maximum likelihood (ML) trees of nucleotide sequences estimated using the dnaml program [ 74], part of the PHYLIP package [ 75].
The flux in the higher energy part is thus calculated by integrating the average distribution function, while the flux in the lower energy part is estimated using the fitting procedure described in the previous section.
First, the parameters of the DRM are estimated using the training dataset (i.e., part of historical data).
The core genome was estimated using the Phylogenetic profiler tool that is part of the IMG system (https://img.jgi.doe.gov/cgi-bin/er/main.cgi) at a similarity cutoff of 50%.
Burnout in Part 3 was estimated using the Chinese Maslach Burnout Inventory (CMBI), with a total of 15 items developed by Li YX (2005) and verified as valid [ 35].
Protein concentration was estimated using the Micro BCA Protein Assay Kit Thermoo).
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