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IL-1β levels were estimated using human IL-1β ELISA kit Diaclone-Eli-pair (Besancon, France).
The highest mean absorbed doses estimated using human PET data were observed in the gallbladder (333 ± 251 μGy/MBq), liver (77.5 ± 14.5 μGy/MBq), small intestine (33.6 ± 30.7 μGy/MBq), upper large intestine (29.8 ± 15.0 μGy/MBq) and lower large intestine (25.2 ± 12.6 μGy/MBq).
Selection coefficients followed a gamma distribution of parameters α = 0.2 and β = 2.5, which were estimated using human polymorphism data (Keightley and Eyre-Walker 2007).
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Since the mouse data is measured with regards to 789 nm, the estimate using human data is also shifted laterally so that LCA is 0 at 789 nm. Figure 5 shows that the measured mouse LCA is in good agreement with estimates using human LCA data.
For employed workers, labour cost was estimated using the human capital method, based on the cost of the working hour reported in the Quarterly Survey of Labour Costs during the Fourth Quarter of 2010 [33].
In order to find novel quinazoline compounds with same enzyme sites as 4-anilinoquinazoline, a series of 4-thiosemicarbazide quinazolines were synthesized by He et al.[75], and their anti-cancer activities were estimated using 5 human cancer cell lines with 5-FU as reference.
4 The economic cost of deaths was estimated using the human capital approach based on productivity losses.
Societal costs will be estimated from a wider societal perspective including NHS costs as above, DLA and lost work productivity estimated using a Human Capital approach.
h and a are unknown and have been estimated using the human counted cell numbers as the training dataset (h ≈ 4.0 and a ≈ 0.5).
Indirect costs due to sick leave were estimated using the human capital approach, which measures productivity losses by multiplying the work time lost as a consequence of illness by the gross earnings of the individuals affected.
The cost to society of on non-paid assistance to MS patients by relatives and friends at times when the providers would alternatively have performed paid work was estimated using the human capital method.
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