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Additionally, fibre intake, enterolignan levels, and lignan-rich foods (except for the seeds) were estimated using a validated dietary questionnaire.
The latter was estimated using a validated mathematical model of metabolism relating body weight to the amount of food eaten.
The BLRharm(i) can be estimated using a validated CPG.
SB intake was estimated using a validated semi-quantitative food frequency questionnaire.
CMRO2 was estimated using a validated neurovascular coupling model (eq. 1) (Davis et al. 1998).
Risk model performance was estimated using a validated bootstrap bias-correction procedure.
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The day of ovulation (or luteal transition) was estimated using a previously validated algorithm based on the ratio of E1C to PdG during 5-day windows where E1C was declining and PdG was increasing (Baird et al. 1990; Waller et al. 1998; Windham et al. 2002).
We obtained 3D locations of new bone formation by performing 'slice and view' 3D fluorochrome mapping of the entire bone and compared these sites with the regions of high fluid velocity or strain energy density estimated using a finite element model, validated with ex-vivo bone surface strain map acquired ex-vivo using digital image correlation.
The fluid film pressures, foil deflections and rotor movements are simultaneously solved, considering foil stiffness and damping coefficients estimated using a structural model, previously described and validated against experiments.
The population prevalence of each variant identified was estimated using a series of 6,448 newborn controls and a previously described and validated pooling strategy [ 16].
To validate the workings of the proposed model, eight scenarios are simulated through a unique parameter value set which was estimated using a systematic approach.
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