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By 2012 more than 140 institutions had enrolled, estimated to reflect surveillance of <5% of transfusions.
The QALY is estimated by weighting survival with a value reflecting the HRQL experienced during the time period, where the HRQL value is estimated to reflect the 'utility' of the health state.
Size exclusion chromatography showed that much of the endogenous pool of PARP1 resides in rather low-molecular-weight complexes in whole-cell extracts (peaking in fraction 15), estimated to reflect monomeric PARP1.
To better understand how ribozyme activity could be modulated in cultured mammalian cells, a group I intron was inserted into a short hairpin RNA (shRNA), and silencing of a reporter gene by the shRNA was estimated to reflect self-splicing activity in vivo.
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The government said it cut its fourth-quarter growth estimate to reflect the latest data for inventories, exports and imports.
The complicating factor is that at the start of every year, the B.L.S. updates its population estimates to reflect new information from the Census Bureau.
Banc of America said it reduced its estimates for Intel's first-quarter revenue and earnings per share estimates "to reflect weaker-than-expected notebook PC demand".
However, due to the widespread evidence of recent population decline of A. cervicornis and the tendency of effective population size estimates to reflect the long-term average (harmonic mean) population size [54], our effective population size estimate may not significantly underestimate the true census size of genetically distinct colonies of this species in the Florida Keys.
It was recalibrated to mirror the 10-year follow-up data from MASS; the main cost parameters were re-estimated to reflect current practice; and more robust estimates of AAA growth and rupture rates from recent meta-analyses were incorporated, as were key parameters as observed in NAAASP (attendance rates, AAA prevalence and size distributions).
The new cost estimates demonstrate that, although simple adjustment using relevant price indices may be adequate for some unit costs, for some the procedure costs need to be re-estimated to reflect changes in the costs of particular resources, and changes in the process of care.
As the Kalman filter updates the state estimates to reflect a patient's particular characteristics, that patient's trajectory becomes more dissimilar to the trajectories of other patients.
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