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The power was estimated to detect a difference in AE rates between different hospital types.
More than 80% power was estimated to detect a 1.5-fold difference in various biomarker concentrations for the given sample size.
The sample size for the evaluation of PRO score change after RAMP-HT is estimated to detect a minimally clinically important difference (MCID) that is equivalent to Cohen's small effect size of 0.3 [ 20].
The sample size was estimated to detect a statistically significant difference in the carotid IMT that was greater than or equal to 0.03 mm between baseline and the fourth assessment.
The sample size was estimated to detect a minimum difference between a dissatisfaction rate of 5% in one arm and 10% in the other, with a two-sided test at a significance level of 5%, and with 80% power.
The sample size for the evaluation of quality of life change after RAMP is estimated to detect a minimally clinically important difference (MCID) in health-related quality of life (HRQOL) studies that is equivalent to Cohen's small effect size of 0.3 [ 22].
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Statistical power was estimated to detect an OR of 1.50/0.67 (for a risk/protective effect), with an α level equal to the observed P value [ 20].
A sample size requirement of 36 was estimated to detect an effect size of 0.8, powered at 80% and alpha of 5% was chosen for a clinically meaningful estimate.
Using these data and assuming a liver-dominant:liver-only ratio of 40 60, a sample size of at least 450 patients for the SIRFLOX study was estimated to detect an increase in the median PFS from 9.4 months to 12.5 months with 80% power and 95% confidence.
Sanz et al. reported similar findings in 1999, with 18F-FDG PET unable to reliably detect lymph node metastases [ 17]. 18F-FDG has been estimated to detect nodal metastases with a Se ranging from 0 to 50% and a Spe ranging from 72 to 90% [ 18].
Site-specific changes in evolutionary rate after gene duplication (type I functional divergence) was estimated to detect functional divergence of a protein family [31], [50].
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