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We computed the change of RNA structure for each exonic SNP with several different measures (Sabarinathan et al. 2013; Salari et al. 2013) and estimated its effect on local RNA structure through these calculations.
For a given SNP V, we estimated its effect on the binding of a particular transcription factor tf, denoted by the matching score S tf (V), by evaluating the binding affinity differences between reference and alternative alleles; the binding affinity was calculated using the position weight matrices (PWMs) documented in the TRANSFAC database using previously published methods (Wang et al., 2008).
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For example, Smith et al. (2009) estimated its effects among 352,000 participants in the ACS cohort and reported a relative risk (RR) of 11%9595% CI: 3, 19) per 1 μg/m.
Dr. Christakis and Dr. Fowler focused on this as a cause of obesity, saying that they could estimate its effect and that it was large.
Isolation of the intra-individual effect by means of the dummy variable method distinguished the effect of temperature from the other contributions as the ventilatory volume of the same subject was kept constant at the different temperatures, and made it possible to estimate its effect on the parameters describing the regression.
Most importantly, both evaluators and stakeholders should be aware of RTM as a major source of bias in intervention studies, and take the appropriate steps to estimating its effect and controlling for it whenever possible to ensure valid conclusions about program effectiveness.
Concerns about RTM are rarely raised in connection with most health care interventions, and it is uncommon to find evaluators who estimate its effect.
We then looked at sales in the four weeks before and after a review to estimate its effect.
The earth itself is embroidery and my treading on it is communicated through a network so complex even the mightiest computer can't estimate its effect".
At the end of dosing left ventricular functions was assessed to estimate its effect on cardiac functions.
By comparing the responses of people interviewed before and after the announcement, he could estimate its effect on public opinion about AIDS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com