Substitution model misspecification can result from: (1) estimating insufficient parameters to fit the evolutionary process, and/or (2) estimating such parameters incorrectly.
However, a number of important limitations of TTE are related to the lack of sufficient tricuspid regurgitation to estimate sPAPTTE, insufficient reliability in the context of coexistent lung disease, potential poor acoustic windows related to body habitus, the need for specific expertise in technique and interpretation, as well as issues related to cost and resource allocation [ 14, 17].
In one animal, the cartilage surface area and volume of the tibial aspect of the knee could not be estimated due to insufficient data to perform adequate 3D reconstruction of this section; this animal does not contribute data to the total knee volume and surface area analyses.
An obvious limitation of this study is that the sample size was relatively small with one animal's cartilage surface area and volume of the tibial aspect of the knee not being estimated due to insufficient data to perform adequate 3D reconstructions of this section.
Economic growth had already begun to slow significantly in the years prior to the crisis and the English rural population was increasingly under economic stress, with around half the peasantry estimated to possess insufficient land to provide them with a secure livelihood.
The effect of prediagnostic IgE levels on different subtypes of glioma was not estimated due to insufficient included publications.
Fourth, prior antibiotic use could not be fully estimated due to insufficient information from other clinics in the medical records.
Efficient conservation management is particularly important because current spending is estimated to be insufficient to conserve the world's biodiversity.
When, for instance, job demands are perceived as high and individual skills are estimated to be insufficient, then these three dimensions are perceived as being out of balance.
Efficient management is particularly important because current spending is estimated to be insufficient to conserve the world's biodiversity; indeed, a 10-fold increase in funding might be necessary.
Reported vaccination coverage in Malawi prior to the epidemic in 2010 was high countrywide, with variations in coverage by district, although in subsequent coverage surveys conducted after the intervention, coverage was estimated to be insufficient (6).
