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When information on ultrasound was not available, gestational age was estimated from date of last menstrual period.
Overall survival (OS) was estimated from date of diagnosis to date of last follow-up or death from any cause.
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Although the fossil remains of MH1 and MH2 were too old to be dated directly, their ages were estimated from dating the uranium-rich flowstone matrix that surrounded them.
The mean rate of nucleotide substitution estimated from dated IHHNV capsid sequences under assumptions of both strict and relaxed molecular clocks were comparable and unexpectedly high for a DNA virus such as IHHNV.
Thus, the gestational weeks for women without that information were estimated from dates using the following algorithm: gestational weeks at first visit in days+days between the first visit and delivery; the days were then transformed into weeks.
Overall survival was estimated from the date of pathological diagnosis to the date of death or date of last follow-up.
AIDS survival time was estimated from the date of AIDS diagnosis to the date of AIDS-related death or censoring date (in months).
Survival was estimated from the date of diagnosis until the date of death (all causes).
Overall survival was estimated from the date chemotherapy commenced to the date of death from any cause.
Overall survival was estimated from the date of diagnosis to the date of death or last follow-up (1 November 2012).
Clinical outcomes were estimated from the date of surgery to the date of death or last follow-up.
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