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Piperaquine, a bisquinoline, is estimated to have an elimination half-life of 2 3 weeks [16]; lumefantrine, an aryl alcohol, has an estimated elimination half-life of 4 10 days [17].
Estimated elimination half-time at steady state was 2.25 minutes.
None of the other parameters investigated was associated with the estimated elimination rates across all congeners.
We identified covariates associated with the estimated elimination rates with p-values of ≤ 0.1.
Conclusions: The estimated elimination rates from this relatively large serial sampling study can inform occupational and environmental exposure and serum evaluations for dioxin compounds.
The estimated elimination half-lives from the present study based on changes in mass are slightly longer than those based on concentration.
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The effective field efficacy can be used to estimate elimination times and program effectiveness.
CSTD provide quantitative information about trends in human exposure and can be combined with exposure studies to estimate elimination kinetics.
In the present study we resampled a subset of chlorophenol workers with previous serum concentration measurements to estimate elimination rates of these dioxins.
We use a case study of DDT (dichlorodiphenyltrichloroethane) to show that CSTD can be combined with exposure data obtained from total diet studies to estimate elimination kinetics of POPs for humans under background exposure conditions.
To estimate elimination kinetics, we fit the model to measured data using a least-square optimization by adjusting three fitting parameters: adult reference intakes in the years 1970 and 2000, and kelim.
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