All data were log-transformed and estimated effect size is given as % estimated effect size calculated for a two-fold increase in urinary cadmium concentrations (μg/g creatinine) with the corresponding 95% confidence interval, R2 gives the explained variance.
Experimental design and n number determination was based on previous experience and appropriate power analyses (α = 0.05, 80% power, 20 50% estimated effect size depending on measure).
That estimated effect size was 1.62.
Before testing independent associations of quantitative traits with IGF2 DMR methylation, Z-scores were calculated so that the resulting estimated effect size indicates the methylation change per standard deviation (SD) change in the parameter tested.
ß coefficients are estimated effect size of intervention on peak expiratory flow rate and FEV1.
We then estimated effect size (ES) using Cohen's techniques as the distribution method [ 32, 33].
Primaquine, a widely utilized antimalarial, additionally generated a 100% estimated effect size at higher dosages (12 and 6 mg/kg).
The primary analysis will compare birth Length-for-Age Z-score (LAZ) among trial arms (independently for each site, estimated effect size: 0.35).
We then calculated the correlation between the estimated effect size from these simulations against minor allele frequency, for detected eQTL only.
Bias in a clinical trial can be defined as a systematic difference between the estimated effect size and the true effect size [ 27].
Drugs with a moderate estimated effect size included A-L, OZ439, and primaquine at 1.25 mg/kg (58%, 57%, and 29%, respectively, at the stated doses), while the estimated effect size for primaquine (alone) at 0.25 mg/kg was comparatively low (8%).
