Sentence examples for estimated constraint from inspiring English sources

The deep split of the lineages investigated could suggest that the estimated constraint constitutes a representative average for birds.

The estimated constraint for 4-fold degenerate sites was 43.1% (±1.6%), 28.8% (±1.8%), and 24.2%±1.4.4%) in the chicken, turkey, and zebra finch lineages, respectively.

One way to handle this potential problem is to weight estimated constraint by the proportion of sequence removed in the neutral reference.

Weighting the estimated constraints to take regions difficult to align in AR into account increases the estimates to 49.9% (±1.9%), 33.4% (±2.1%), and 28.0% (±1.6%), respectively.

For three-species alignments, we used the genome-wide divergence estimates obtained from concatenated sequences to directly estimate constraint as 1 − o/ e.

To widen the knowledge of selection at synonymous sites in vertebrates, we here estimate constraint at 4-fold degenerate sites of avian genes.

Estimating constraint from MSA has been widely applied to predict whether a sequence variant resulting in an amino acid substitution is likely to be deleterious.

If we use AR as a neutral reference to estimate constraint in the other sequence categories, 0-fold degenerate sites show an 86.7% (±0.6%) and 4-fold degenerate sites a 24.2% (±1.6%) constraint.

For example, the Genomic Evolutionary Rate Profiling (GERP) algorithm [ 31] is a widely used method for estimating constraint in genomic sequences as it can assign conservation scores to specific nucleotides, which is clearly of importance when annotating small-scale variation such as single-nucleotide variants (SNVs).

With the estimated PSM constraint for ST i (i =1,2,3,…,K) from DNPSM, we know the maximal allowed transmission power ( P i, j Max ).

Most studies that estimated evolutionary constraint on disordered regions have relied on interspecies comparisons using pairwise alignments of disordered regions across species.