Sentence examples for estimated brain activity from inspiring English sources
Table 2 Scanning protocols and assumed brain activity at scan start that are used to derive the phantom methods of Table 1 PET drug Standard injection activity Accumulation time Standard scan time Estimated brain activity at start of scan FDG 185 MBq 30 min 30 min 20 MBq PiB 555 MBq 50 min 20 min 3 MBq Florbetapir 370 MBq 50 min 20 min 12 MBq Flutemetamol 185 MBq 90 min 30 min 3 MBq.
The % brain uptake was assumed to be 4.5 %ID and 3.0 %ID based on the dosimetry study for 18F-florbetapir [34] and 18F-flutemetamol [35], leading to estimated brain activity of 12 and 3 MBq, respectively.
The % brain uptake of FDG at 30 min post-injection was assumed to be 13 %ID based on the time-%ID curve for the brain [29] leading to estimated brain activity of 20 MBq at 30 min post-injection, with decay taken into account.
The % brain uptake was assumed to be 3%% (0.53 %IRD) based on the brain time-%IRD curve in a previous report [31] (%IRD denotes % injected radioactive dose, which is %ID with decay), leading to an estimated brain activity of 3 MBq.
According to the sponsor company (Piramal Imaging), the standard injection activity, accumulation time, and scan time for 18F-florbetaben are 300 MBq, 90 min accumulation, and 20 min scan, respectively, and the average % brain uptake at 90 min post-injection was 3.5 %ID, based on the data of clinical trials in Japan, leading to the estimated brain activity of 6 MBq at scan start [26].
As a consequence, magnetic resonance signal estimates brain activity related to the changes in blood flow that follow modification of neural activity.
Diffuse optical imaging employing near infrared spectroscopy (NIRS) in human has been utilized in the past during visual stimulation to monitor visual cortical function [ 7] and estimate evoked brain activity and tissue oxygenation [ 8 10].
In total, the GLM to estimate intrinsic brain activity related to slow, spontaneous changes in eye position contained one regressor of interest and 16 co-variates of no interest.
Current techniques for skull attenuation correction (AC) provide indirect estimates of cortical bone density, leading to inaccurate estimates of brain activity.
In the multiple-subject model, the estimate of brain activity is directly obtained in the registered spherical space (inflated cortical surface).
