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In a previous study, where different chromosome positions of the mutNHEJ and GT reporters were taken into account, the I-SceI-induced mutNHEJ GT ratio was estimated at random loci in HCA-2 (human colon cancer) cells to be 6 1 (23).

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The variance of the random error is estimated at 0.111.

Random intercepts were estimated at both item and dataset levels.

The variance of the random variable was estimated at 5.10 -9 (p = 0.9948).

Because within-individual repeated measures of outcomes are correlated, random effects were estimated at the subject level.

The uncertainty in the estimate of per adult sales related to sampling variability (i.e. random error) is estimated at ±0.5 l.

Random effects were estimated at the subject level, nested within seasonal phase and community, to account for correlated within-individual repeated measures.

Because within-individual repeated measures of outcomes are correlated, random effects were estimated at the subject level, nested within phase and community.

On every occasion, the heart rate of two random participants was estimated at each station using Polar pulsimeters (Polar® Accurex Plus, Polar, Sweden).

The variance component for event as a random effect was estimated at 2.27 for PALP and at 0.25 for HOOF with a decrease in the prevalence of findings throughout the study period.

Using these parameters, a simple random sample size would be estimated at 1,475 adolescents.

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